A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort

A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort

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Abstract The contributing genetic factors of vertigo remain poorly characterized, particularly in individuals of non-European ancestries.Here we show the genetic landscape of vertigo stewart copeland drumsticks in an Asian population-based cohort.In a two-stage genome-wide association study (Ncase = 6199; Ncontrol = 54,587), we identify vertigo-associated genomic loci in DROSHA and ZNF91/LINC01224, with the latter replicating the findings in European ancestries.Gene-based association testing corroborates these findings.

Interestingly, both genes are enriched in cerebellum, a key structure receiving sensory input from the vestibular system.Subjects carrying risk alleles from lead SNPs of DROSHA and ZNF91 incur a 1.74-fold midnight drive nail polish risk of vertigo than those without.Moreover, composite clinical-polygenic risk scores allow differentiation between patients and controls, yielding an area under receiver operating characteristic curve of 0.

69.This study identified novel genomic loci for vertigo in an Asian population-based cohort, which may help identifying high risk subjects and provide mechanistic insight in understanding the pathogenesis of vertigo.